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public static byte[] ResizeImageFile(byte[] imageFile, int targetSize)
{
    using (System.Drawing.Image oldImage = System.Drawing.Image.FromStream(new MemoryStream(imageFile)))
    {
        Size newSize = CalculateDimensions(oldImage.Size, targetSize);

        using (Bitmap newImage = new Bitmap(newSize.Width, newSize.Height, PixelFormat.Format32bppRgb))
        {
            newImage.SetResolution(oldImage.HorizontalResolution, oldImage.VerticalResolution);
            using (Graphics canvas = Graphics.FromImage(newImage))
            {
                canvas.SmoothingMode = SmoothingMode.AntiAlias;
                canvas.InterpolationMode = InterpolationMode.HighQualityBicubic;
                canvas.PixelOffsetMode = PixelOffsetMode.HighQuality;
                canvas.DrawImage(oldImage, new Rectangle(new Point(0, 0), newSize));
                MemoryStream m = new MemoryStream();
                newImage.Save(m, ImageFormat.Jpeg);
                return m.GetBuffer();
            }
        }

    }
}

private static Size CalculateDimensions(Size oldSize, int targetSize)
{
    Size newSize = new Size();
    if (oldSize.Width > oldSize.Height)
    {
        newSize.Width = targetSize;
        newSize.Height = (int)(oldSize.Height * (float)targetSize / (float)oldSize.Width);
    }
    else
    {
        newSize.Width = (int)(oldSize.Width * (float)targetSize / (float)oldSize.Height);
        newSize.Height = targetSize;
    }
    return newSize;
}